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KMID : 0356919920250061206
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Korean Journal of Anesthesiology
1992 Volume.25 No. 6 p.1206 ~ p.1211
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Effect of Clonidine Premedication on Isoflurane Induced Hypotensive Anesthesia
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Abstract
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The effect of single dose clonidine premedication on the vapour requirement for isoflurane induced hypotension in 20 patients undergoing spine surgery was evaluated.
The patients given 5μg/kg of clonidine P.O. at 90 minutes before operation required a mean expired isoflurane concentration of 1.2(0.5 vol% to induce hypotension compared with 2.1(0.6vol% in 0.2mg/kg of diazepam predmedication group(P<0.05).
To achieve satisfactory hypotension, six out of ten patients in diazepam premedication group and 1 out of 10 patients in clondine premedication group are required supplementary infusion of sodium nitroprusside.
In conclusion, clonidine premedication is recommended in isoflurane induced hypotensive anesthesia.
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